Field of Study:
Cell and Molecular Biology, Physiology, Neuroscience, and Microbiology
Department:
Department of Neuroscience
Rank of Student:
Junior
Desired Majors:
Molecular Genetics or Biology
Hours per Week:
10
Compensation Type:
Academic Credit
Application Deadline:
Contact:
Lihua Ye: lihua.ye@osumc.edu
Private
Public
Project Description
The intestine harbors a complex microbial community. The microorganisms residing in the intestinal lumen have a significant impact on brain function and behavior. However, the cellular and molecular mechanisms by which gut microbiota modify brain function are unclear. Our lab’s previous research revealed that a group of specialized sensory cells called enteroendocrine cells (EECs) in the intestinal epithelium is able to sense gut bacteria and directly transmit the bacterial information to the vagus nerve, the primary sensory neurons that connect the gut and brain. Gut bacteria can secrete certain metabolites to activate or inhibit the EEC-vagal pathway to change brain activity and function. The Ye lab uses the zebrafish animal model, gnotobiotic technology, and in vivo microscopic imaging to dissect the molecular mechanisms by which gut bacteria talk to the brain. We use genetic recombination, transposase-mediated insertion, and CRISPR-cas9 genetic editing in both bacteria and zebrafish to dissect the signaling pathway that underlies bacterial and brain communication.
Additional Information
We are seeking highly motivated students with a strong commitment to join our research team. The students will not only join a high-energy lab to pursue research in gut-brain communication, but they will also have the opportunity to contribute to publications. For students who meaningfully contribute to the research, a payment can be considered.
Required Applicant Information
CV with previous research experience and research skills, a brief career goal statement, hours that can commit per week, and a list of 1-2 references (optional).
Required or Desired Skills
Confocal microscope imaging and molecular genetics
Faculty Member Lead:
Lihua Ye
Starting Semester:
Summer
Length of Project (in semesters):
4