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Fc receptor-mediated antibody clearance during immune checkpoint therapy in cancer

Field of Study:
Immunology
Department:
Internal medicine
Rank of Student:
Junior and raising senior students ONLY with intention to take one or two years break before graduate school
Desired Majors:
All biology majors preferably Biomedical sciences
Hours per Week:
20
Compensation Type:
Academic Credit,
Salary / Stipend,
Work-Study,
Voluntary Experience
Application Deadline:
Contact:
Latha.Ganesan@osumc.edu
Private
Public
Project Description
This project investigates how immune cells in different tissues contribute to the rapid clearance of immune checkpoint inhibitors, especially in the setting of cancer-induced cachexia. Using mouse models, we aim to identify the tissues and macrophage populations responsible for elevated antibody clearance and explore how Fc receptor expression and function are altered during cancer. Findings from this study could help improve the effectiveness of cancer immunotherapy.
Additional Information
The students will be hired as undergraduate student researcher with salary till they graduate, and latter will be hired as research assistant during their break year. A break year commitment is a must, if student is a raising senior or senior
Required Applicant Information
A detailed CV with all previous research experience.
Required or Desired Skills
Required Skills:
Previous research experience is a must, preferably in Immunological techniques like, Western blotting, flow cytometry, ELISA, Immunofluorescence staining, so student can start contributing to ongoing manuscripts. Background in cell culture or molecular biology techniques. Strong interest in immunology, cancer research, and laboratory techniques. Ability to work with mouse models and understand Conditional and floxed mice breeding. Strong organizational skills and attention to detail. Ability to work independently and as part of a team. Good communication skills and the ability to present research findings in lab meetings.
Desired Skills:
Previous experience working with tumor-bearing mouse models.
Ability to learn new techniques quickly and apply them to ongoing research projects.
Faculty Member Lead:
Latha Prabha Ganesan
Starting Semester:
Summer
Length of Project (in semesters):
4