Field of Study:
Mechanisms of drug resistance, metastasis and immune evasion in colorectal cancer
Department:
Cancer Biology and Genetics
Rank of Student:
First/Second year honors student preferred, will consider Junior.
Desired Majors:
Biology and chemistry-related majors.
Hours per Week:
12
Compensation Type:
Voluntary Experience
Application Deadline:
Contact:
jing.wang@osumc.edu
Private
Public
Project Description
Research in Dr. Wang’s laboratory includes basic and translational research projects, aiming to 1) understand the molecular mechanisms of colorectal cancer metastasis, drug resistance and immune evasion, 2) identify and validate novel therapeutic targets using cell culture, organoids, mouse models and patient-derived xenografts (PDXs) and 3) develop small molecule inhibitors and test their efficacy in vitro and in vivo. The main goal is to develop novel and effective therapies that can be taken to the clinical trials.
Recently, checkpoint blockade immunotherapy has shown promising results in a variety of cancers including colorectal cancer. As existing immune checkpoint therapies are not universally effective and may be limited by toxicities, discovery of other immunotherapeutic targets and combination strategies is a priority. Dr. Wang’s laboratory has recently developed several projects aiming to identify new therapeutic avenues and facilitate development of novel strategies to prevent cancer immune evasion and increase therapeutic efficacy of immunotherapy.
Recently, checkpoint blockade immunotherapy has shown promising results in a variety of cancers including colorectal cancer. As existing immune checkpoint therapies are not universally effective and may be limited by toxicities, discovery of other immunotherapeutic targets and combination strategies is a priority. Dr. Wang’s laboratory has recently developed several projects aiming to identify new therapeutic avenues and facilitate development of novel strategies to prevent cancer immune evasion and increase therapeutic efficacy of immunotherapy.
Additional Information
No
Required Applicant Information
Resume, transcript and available time to work in the lab.
Required or Desired Skills
Preferred introductory chemistry and biology coursework.
Faculty Member Lead:
Jenny Wang
Starting Semester:
Autumn,
Spring,
Summer
Length of Project (in semesters):
4