Field of Study:
Genetics, Neuroscience, Microbiology
Department:
Department of Neuroscience
Rank of Student:
sophomore
Desired Majors:
Molecular Genetics, Microbiology or Biomedical science
Hours per Week:
12
Compensation Type:
Academic Credit
Application Deadline:
Contact:
Lihua Ye (lihua.ye@osumc.edu)
Private
Public
Project Description
The intestine harbors a complex microbial community. The microorganisms residing in the intestinal lumen have a significant impact on brain function and behavior. However, the cellular and molecular mechanisms by which gut microbiota modify brain function are unclear. Our lab’s previous research revealed that a group of specialized sensory cells called enteroendocrine cells (EECs) in the intestinal epithelium is able to sense gut bacteria and directly transmit the bacterial information to the vagus nerve, the primary sensory neurons that connect the gut and brain. Gut bacteria can secrete certain metabolites to activate or inhibit the EEC-vagal pathway to change brain activity and function. The Ye lab uses the zebrafish animal model, gnotobiotic technology, and in vivo microscopic imaging to dissect the molecular mechanisms by which gut bacteria talk to the brain. We use genetic recombination, transposase-mediated insertion, and CRISPR-cas9 genetic editing in both bacteria and zebrafish to dissect the signaling pathway that underlies bacterial and brain communication.
Required Applicant Information
CV with previous research experience, brief career goal statement, and list of 1-2 references (optional).
Required or Desired Skills
We are seeking motivated students who can commit at least two semesters with a background in molecular genetics, microbiology, or neuroscience.
Faculty Member Lead:
Lihua Ye
Starting Semester:
Autumn
Length of Project (in semesters):
4